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The problem
Intervention: Routine immunization according to Swiss national immunization schedule, with serological monitoring of vaccine response
Who it was tested with: 41 children with PFAPA syndrome followed at Geneva University Hospitals.
Experience from people who deliver programmes: stories, case studies and lessons learned. Valuable for understanding how and why, and for spotting what to test next, but not a measure of effect.
"We conducted a prospective study of children with PFAPA followed at Geneva University Hospitals between February 2022 and April 2025. Clinical, laboratory, and genetic data were collected, along with vaccination status according to the Swiss national immunization schedule and serological results for major vaccine antigens." The study demonstrates that children with PFAPA can be safely vaccinated according to standard schedules with adequate immune responses, though it lacks a control group and does not measure vaccine-triggered episodes.
Single-center study with no comparison group; does not evaluate vaccine reactogenicity or whether vaccination triggers febrile episodes; small sample size limits generalizability
Across countries and designs
7 studies · 8 countries
