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The problem
Intervention: No intervention was tested; this is an observational study examining the association between maternal Zika virus infection and child developmental outcomes
Who it was tested with: Children born in French Polynesia 2013-2016, including those exposed to maternal Zika virus infection in utero and comparison children born without known birth defects.
Experience from people who deliver programmes: stories, case studies and lessons learned. Valuable for understanding how and why, and for spotting what to test next, but not a measure of effect.
"Using a case-control study design, we investigated the temporal association of a cluster of congenital defects with Zika virus infection. In a nested study, we also assessed the early childhood development of children recruited in the initial study as controls who were born without known birth defects." The case-control design with nested assessment constitutes an experimental observational approach, though the lack of randomisation and reliance on retrospective infection data limits causal inference.
Study measured only early childhood development with no long-term follow-up; timing of maternal infection was often unknown; only children without known birth defects were assessed for developmental outcomes
Across countries and designs
18 studies · 28 countries
