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The problem
Intervention: Measurement and assessment of prenatal aromatic amine exposure and infant cognition using biomarkers and eye-tracking visual recognition memory task
Who it was tested with: 250 pregnant women and their infants from two prospective birth cohorts (Illinois Kids Development Study and Chemicals in Our Bodies).
Children or communities are compared with a group that did not receive the intervention, or followed over years. This is the design that best separates what the intervention did from everything else that changed.
"We used linear regression to examine associations between individual natural log transformed AAs and their molar sum with VRM outcomes. We examined effect modification and interaction by child sex." The study prospectively assessed prenatal exposure biomarkers and measured infant cognition using a validated, sensitive eye-tracking task at a developmentally important period, allowing examination of whether chemical exposure during pregnancy relates to early neurodevelopment.
Observational design cannot establish causality; most confidence intervals crossed zero indicating weak associations; small sample size; single cognitive assessment at one timepoint limits ability to assess developmental trajectories or longer-term effects; unmeasured confounding may influence results
Across countries and designs
5 studies · 3 countries
