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The problem
Intervention: Different meningococcal vaccination schedules including options with pentavalent meningococcal vaccine (MenABCWY) replacing separate conjugate and serogroup B vaccines
Who it was tested with: Hypothetical cohort of 11-25 year-old adolescents and young adults in the United States.
Experience from people who deliver programmes: stories, case studies and lessons learned. Valuable for understanding how and why, and for spotting what to test next, but not a measure of effect.
"We used a static, incidence-based population model to compare invasive meningococcal disease (IMD) incidence and mortality, quality-adjusted life years (QALYs), and costs." The study applies mathematical modelling to project the epidemiological and economic impacts of different vaccination strategies, comparing scenarios to the current recommended schedule.
Model-based study with projected outcomes rather than empirical data from actual implementation. Results depend on model assumptions about vaccine effectiveness, disease incidence, coverage rates, and cost parameters that may not reflect real-world conditions.
Across countries and designs
2 studies · 2 countries
