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The problem
Intervention: One-month nutritional intervention provided either as nutritional advice alone or nutritional advice plus oral nutritional supplements
Who it was tested with: Indonesian infants aged 6-12 months with weight faltering.
The same group is measured before the intervention and again afterwards, with a baseline and an endline and sometimes a midline. Change is visible, but other causes cannot be ruled out.
"Infants were assigned to either a Nutritional Advice (NA) group or a Nutritional Advice plus Oral Nutritional Supplements (NAONS) group. Stool samples were collected before and after the intervention for microbiome (16S rRNA sequencing) and metabolome (LC-MS) analysis." The study measured the same infants before and after intervention with no concurrent control group, making it a pre-post design that demonstrated improvements in gut health markers following nutritional intervention.
No randomized control group without intervention; no long-term follow-up beyond one month; no specification of sample size or demographic details; no measurement of stunting prevention or developmental outcomes; no significant correlations found between microbiome and metabolome changes, suggesting complex mechanisms not fully captured.
Across countries and designs
3 studies · 2 countries
