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The problem
Intervention: Vitamin D supplementation during pregnancy (doses ranging across trials)
Who it was tested with: 5405 pregnant women and their offspring across 24 randomized controlled trials.
Children or communities are compared with a group that did not receive the intervention, or followed over years. This is the design that best separates what the intervention did from everything else that changed.
"Randomized clinical trials of vitamin D supplementation during pregnancy and offspring outcomes" were systematically identified through "searches of Medline, Embase, and the Cochrane Database of Systematic Reviews... up to October 31, 2017," with "two authors independently [extracting] data, and the quality of the studies was assessed." This approach combines evidence from multiple randomized trials to establish causal associations between vitamin D supplementation and offspring outcomes.
Meta-analysis of trials with potential heterogeneity in study quality, dosing regimens, and populations; unclear what constitutes clinically meaningful differences in birth weight and growth; subgroup analysis by dose had limited statistical power
Across countries and designs
2 studies · 1 country
