Search reports, ask a question, or jump to a page.
The problem
Intervention: Measurement of plasma B-vitamin levels (riboflavin, niacin, pyridoxine, folate, cobalamin) in children with septic shock to evaluate deficiency status
Who it was tested with: 79 children aged 6 months to 12 years with fluid-refractory septic shock from an LMIC, compared to 22 sibling controls and 64 external controls from an immunization clinic.
Experience from people who deliver programmes: stories, case studies and lessons learned. Valuable for understanding how and why, and for spotting what to test next, but not a measure of effect.
"Plasma levels of riboflavin, niacin, pyridoxine, folate, and cobalamin were measured at enrolment, and patient survival was assessed as the primary outcome." The study documents associations between B-vitamin deficiencies and septic shock outcomes but cannot prove interventions would improve survival without a treatment trial.
The study is observational and cannot demonstrate causal relationships between B-vitamin levels and septic shock outcomes. The country of origin is not specified. Sample sizes for some comparisons are small. Survival data analysis is incomplete in the abstract provided.
Across countries and designs
2 studies · 1 country
Not yet reviewed by a person. Model output is not AICS's view until reviewed.
claude-haiku-4-5-20251001 · synth-v1
