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19,730 reports · page 844 of 1973

Peer-reviewed articlePubMed (US National Library of Medicine)11 Jun 2026

Corifollitropin alfa N02 versus recombinant FSH for ovarian stimulation: a phase 3 trial and safety study in Chinese women.

RESEARCH QUESTION: What is the efficacy and safety of corifollitropin alfa N02, a long-acting FSH analogue, in comparison with daily recombinant FSH (rFSH) for ovarian stimulation in Chinese women? DESIGN: In this double-blind, multicentre trial (NCT06091436), 474 women aged 20-39 years with a normal ovarian reserve were randomized 1:1 to a single subcutaneous dose of corifollitropin alfa N02 (100/150 μg; n = 238) or daily rFSH (150/225 IU; n = 236) for the first week of stimulation, followed by individualized daily rFSH from day 8. The primary objective was non-inferiority in the number of oocytes retrieved (margin -3). RESULTS: The corifollitropin alfa N02 group demonstrated non-inferiority, with a mean of 12.1 oocytes retrieved versus 10.9 in the daily rFSH group (estimated difference 1.2, 95% CI 0.23-2.12). The clinical pregnancy rate was 46.3% in the corifollitropin alfa N02 group and 51.1% in the daily rFSH group, and the ongoing pregnancy rate was 38.8% and 44.3%, respectively. Safety profiles were similar: ovarian hyperstimulation syndrome occurred in 3.8% of women in the corifollitropin alfa N02 group and 2.5% of women in the daily rFSH group, and treatment-related adverse events occurred in 15.2% and 11.0% of women, respectively. Pooled data from phase 2 and 3 trials reported neonatal outcomes at 12 months, with a birth defect rate of 7.6% for the corifollitropin alfa N02 group and 12.0% the daily rFSH group. Anti-drug antibodies were detected in 3.0% of women in the corifollitropin alfa N02 group without clinical impact. CONCLUSIONS: A single dose of corifollitropin alfa N02 was non-inferior to daily rFSH in terms of oocyte yield, with similar safety, offering a simplified ovarian stimulation alternative for Chinese women with a normal ovarian reserve.

Tingting Li, Xiujuan Chen, Yingpu Sun et al.

Peer-reviewed articlePubMed (US National Library of Medicine)21 Apr 2026

Negotiating Multiple Minoritised Identities: An Interpretative Phenomenological Analysis of Intersecting Sexual Orientation, Gender Identity, and Suicidal Thoughts and Behaviours Among Transgender and Gender-Diverse Young Adults.

UNLABELLED: Transgender and gender-diverse young adults, most of whom identify as lesbian, gay, bisexual, or queer, encounter considerable health, social, and systemic inequalities, leading to higher rates of trauma exposure, mental health difficulties, and suicidal thoughts and behaviours compared to their heterosexual and cisgender peers. The complex relationship between sexual orientation, gender identity, and suicide has received considerable attention, primarily from quantitative research focused on risk narratives, rather than an individual's lived experiences or specific healthcare needs. The aim was to explore the lived experiences of transgender and gender-diverse young adults, highlighting the impact of navigating multiple minoritised identities, exposure to trauma, victimisation, unmet healthcare needs, suicidal distress, and barriers and facilitators to accessing mental health services and gender-affirming care. Six young adults from Northern Ireland (UK) were recruited via social media and participated in semi-structured interviews. Interviews were audio-recorded, transcribed verbatim, and analysed using Interpretative Phenomenological Analysis (IPA), following a process of coding, theme development, and interpretative synthesis. Five group experiential themes were identified: (1) Delicate peace, delicate progress; (2) Queer suffering, safety and otherness; (3) Queerness shaping ones' worldview; (4) Unresolved trauma, and unmet healthcare needs; (5) Suicidal distress, and recovery. The findings elucidated two central narratives; the psychosocial impact of negotiating multiple minoritised identities in a heteronormative and cisnormative society and navigating suicidal distress by regaining a sense of control over your life. The findings provide valuable insights into the unique lived experiences, and specific healthcare needs of this population. Clinical implications are discussed, including the importance of trauma-informed care, cultural competence among healthcare practitioners, and tailored suicide prevention strategies for LGBTQ+ youth. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at https://doi.org/10.1007/s40653-026-00877-4.

Emma Rebecca Wallace, Siobhan O'Neill, Susan Lagdon

ProtectionDevelopmentIERead at source

Peer-reviewed articlePubMed (US National Library of Medicine)1 Sept 2026

Evidence for Social Media Legislation Strategies.

IMPORTANCE: Social media use has grown rapidly, with particularly high adoption among adolescents. These patterns carry both risks, such as problematic use, and potential benefits, such as social connection, creating challenges for policymakers developing regulatory approaches. OBJECTIVE: To synthesize existing evidence and policy approaches related to legislative efforts addressing adolescent social media use and to assess the potential risks, benefits, and evidence gaps associated with commonly proposed or implemented policy strategies. EVIDENCE REVIEW: Evidence was identified through database searches from PubMed and Web of Science focused on policies and legislative proposals from August 1, 2003, to March 22, 2026, targeting adolescent social media use. Policy categories included warning labels, age restrictions and assurance (eg, verification), parental consent and monitoring, school phone policies, platform design regulations, and legislation addressing deepfakes and nonconsensual intimate images. FINDINGS: The search yielded 672 articles, of which 39 met inclusion criteria. Most publications addressed parental consent and monitoring (n = 12), deepfakes and nonconsensual intimate images (n = 8), age restrictions and assurance (n = 7), and design bills (n = 6), with fewer articles examining school phone policies (n = 4) and warning labels (n = 2). Warning labels may increase awareness of potential risks, although data largely consisted of expert opinion. Age assurance measures were commonly circumvented, and proposed biometric or artificial intelligence (AI)-based verification methods had unresolved challenges. Parental monitoring and consent were associated with lower problematic social media use and positive adolescent outcomes in survey-based publications. School phone restriction policies were widely adopted, but evidence regarding academic, social, or mental health effects was limited. Design-focused legislation, such as the Kids Online Safety Act and Age-Appropriate Design Bills, emphasized platform accountability, transparency, and safeguards for minors. Policies addressing AI-generated sexual deepfakes and nonconsensual intimate images aimed to reduce exposure to psychologically harmful material, although evaluation of their effectiveness was limited. CONCLUSIONS AND RELEVANCE: In this review of legislative approaches to adolescent social media, observational and expert-opinion publications provided preliminary insights into potential benefits and risks, but systematic evidence evaluating the effectiveness and unintended consequences was limited. Rapid research, including timely evaluation of newly enacted legislation, is needed to assess the effects of different policy approaches and support the iterative, collaborative development of theory-driven, child-centered policies.

Jason M Nagata, Sahana Nayak, Oliver H Huang et al.

ProtectionParticipationRead at source

Peer-reviewed articlePubMed (US National Library of Medicine)25 Jul 2026

Sleep-deprived and behind the wheel: Exploring the impact of sleep patterns on new parents' driving behavior.

INTRODUCTION: New parents commonly experience sustained sleep disruption in the postpartum period, yet their road-safety risk remains under-examined. This study investigated sleep patterns, the prevalence of fatigued driving, risk awareness, and fatigue-management strategies among Australian parents with at least one child under 12 months. METHOD: A cross-sectional design using an online survey was conducted using Qualtrics. Measures included sleep quantity and quality (modified Pittsburgh Sleep Quality Index), frequency and symptoms of fatigued driving, self-reported driving behavior (Driver Behavior Questionnaire), comparative risk awareness, and use of behavioral and technological fatigue-mitigation strategies. RESULTS: Among the 1,160 responses included in the analysis, participants reported substantial sleep disruption, averaging six hours of sleep per night with generally poor sleep quality. Over 90% reported driving while fatigued at least once in the past 30 days. Common self-observed symptoms included poor concentration, tired eyes, increased blinking, and an increased likelihood of driving errors. Participants who reported fatigued driving also reported significantly higher levels of aberrant driving behaviors (Aggressive Violations: t(1015) = -2.59, p = 0.01; Violations: t(1015) = -4.71, p < 0.001; Lapses: t(1015) = -6.23, p < 0.001; Errors: t(103) = -7.17, p < 0.001). Fatigued driving was reported more frequently than speeding, mobile phone use, or alcohol- and drug-impaired driving. Fatigue management relied primarily on short-term behavioral strategies such as caffeine intake and in-vehicle stimulation, while uptake and perceived effectiveness of fatigue-detection technologies were limited. CONCLUSIONS: New parents experience pronounced sleep disruption and frequently engage in fatigued driving associated with higher crash-risk behaviors. These findings highlight the need for greater attention to fatigue-related driving risk during early parenthood. PRACTICAL APPLICATIONS: Targeted road-safety messaging, healthcare-provider advice, supportive workplace policies, and clearer communication about fatigue-detection technologies may reduce fatigue-related driving risk during early parenthood.

Sjaan Koppel, Hayley McDonald, Yue-Ling Ueng et al.

AURead at source

Peer-reviewed articlePubMed (US National Library of Medicine)5 Sept 2026

Eco-Emotion Profiles Among Parents and Links to Violent and Neglectful Parenting: Parental Burnout as a Mediating Pathway.

Climate change is a psychosocial stressor with implications for parenting and child safety. Many parents experience eco-emotions that can tax caregiving resources and self-regulation, yet evidence is scarce on how eco-emotion profiles relate to parental burnout and violent and neglectful parenting. This study aimed to identify eco-emotion profiles and to test whether parental burnout explains associations with psychological aggression, physical assault, and neglect toward children. Participants were 1,203 cisgender heterosexual Italian parents (70.16% mothers; M = 45.60, SD = 9.37) who completed self-report measures through an online survey. Latent profile analysis of eco-anxiety, eco-guilt, eco-grief, solastalgia, and eco-paralysis identified eco-emotion profiles; structural equation modeling tested direct and indirect effects of profile membership on maltreatment outcomes via parental burnout. Three profiles emerged: Eco-disengaged (18.8%), Eco-concerned (60.6%), and Eco-distressed (20.7%). Eco-distressed parents reported higher parental burnout than eco-concerned parents (standardized mean difference [SMD] = 0.324, p < .001). Parental burnout predicted psychological aggression (β = .370), physical assault (β = .288), and neglect (β = .525; all ps < .001). Eco-distressed membership showed positive indirect associations via parental burnout on psychological aggression (SMD = 0.120), physical assault (SMD = 0.093), and neglect (SMD = 0.170), with all 95% bootstrap CIs > 0, as well as a negative direct association with psychological aggression (SMD = -0.193, p = .014). Climate-related distress may function as an emerging caregiver risk factor, emphasizing the need for preventive interventions that strengthen parental resources and address climate-related emotional burden within child protection frameworks.

Nicola Carone, Jacopo Tracchegiani, Gianluca Cruciani et al.

ProtectionPractitionerITRead at source

Peer-reviewed articlePubMed (US National Library of Medicine)5 Sept 2026

Strategies to Promote HIV Self-Testing and Long-Acting Injectable PrEP Among Ghanaian Youth: Results from the Y-FIT GH National Crowdsourcing Open Call.

Crowdsourcing is a participatory problem-solving approach that engages a large and diverse group of individuals to generate ideas or solutions. In HIV prevention, it provides a structured mechanism for involving youth in shaping intervention strategies. The Innovative Tools to Expand Youth-Friendly HIV Self-Testing and Long-Acting Injectable PrEP Uptake in Ghana (Y-FIT GH) National Open Call applied this method to generate youth-driven ideas to promote HIV self-testing (HIVST) and long-acting injectable PrEP (LAI-PrEP) in Ghana. This study describes youth responses to the open call and identifies strategies they proposed to strengthen HIV prevention among their peers. Ghanaian youth aged 15-24 years were invited to submit creative entries illustrating how HIVST and PrEP could be promoted and accessed by young people. Submissions were received through online platforms and community-based channels between May and August 2025. Following independent review, 103 eligible entries from 12 regions were qualitatively analyzed using an inductive multimodal approach. Written narratives (32%), posters (19%), and audiovisual pieces (18%) were the most common. Six interconnected thematic domains were identified: (1) HIVST and PrEP as pathways to autonomy, safety, and self-respect; (2) creative, peer-led, and culturally resonant communication; (3) multilevel, hybrid delivery models prioritizing accessibility, familiarity, and privacy; (4) stigma shaping youth engagement; (5) gaps in navigation, support, and trust in existing services; and (6) AI and AI-enabled chatbots as emerging channels for confidential information and peer support. The contest effectively engaged Ghanaian youth and generated actionable, contextually grounded strategies to enhance HIVST and PrEP uptake.

Gloria Aidoo-Frimpong, Abass Tando Abubakar, Yaa Adutwumwaa Obeng et al.

SurvivalProtectionParticipationGHRead at source

Peer-reviewed articlePubMed (US National Library of Medicine)5 Sept 2026

Parental Preferences for Continuous Glucose Monitoring Devices in Children with Type 1 Diabetes: A Pilot Discrete Choice Experiment with Sensitivity Analysis of Decision Consistency.

BACKGROUND: Continuous glucose monitoring is increasingly used in pediatric type 1 diabetes management, but families may value device characteristics differently and may trade off convenience, safety-related functions, remote data access, sensor replacement burden, and cost. PURPOSE: This pilot discrete choice experiment explored parental preferences for continuous glucose monitoring device attributes among Chinese families of children with type 1 diabetes and examined the robustness of preference estimates under alternative respondent-inclusion and modeling strategies. PATIENTS AND METHODS: Parents or legal guardians of children with type 1 diabetes completed an online discrete choice experiment. Each of ten core choice tasks presented two hypothetical continuous glucose monitoring devices and an opt-out option representing maintenance of the child's current monitoring strategy. Five attributes were included: measurement and calibration, low-glucose alert, remote monitoring, sensor replacement frequency, and monthly cost. The revised primary analysis excluded only responses with implausible or atypical completion times and retained respondents who failed the dominance task or consistently selected the opt-out option. Non-cost attributes were modeled categorically using effects-coded conditional logit models with cluster-robust standard errors at the respondent level. Sensitivity analyses applied alternative respondent-inclusion criteria. RESULTS: Among 79 initial responses, 75 respondents were included in the revised primary analysis, contributing 750 core choice tasks and 2250 alternative-level observations. Real-time remote monitoring with automatic push notification showed a positive association with device choice in the revised primary analysis, although the estimate did not reach conventional statistical significance. This attribute remained positive and statistically significant in sensitivity analyses excluding dominance-task failures, excluding consistent opt-out respondents, and applying the original strict quality-control criteria. A 14-day sensor replacement frequency was positively associated with device choice in the revised primary analysis, whereas 30-day replacement did not show a consistent additional preference advantage. Measurement/calibration, low-glucose alert functions, and monthly cost showed less stable associations across analyses. Exploratory relative-importance analysis suggested that remote monitoring may be an important preference driver. Willingness-to-pay estimates were exploratory and should be interpreted cautiously because of imprecision in the cost coefficient. CONCLUSION: In this pilot study, real-time remote monitoring emerged as the most consistent positive preference signal for continuous glucose monitoring device choice among parents of children with type 1 diabetes. Preferences for sensor replacement frequency appeared nonlinear, and estimates for other attributes were less stable. These findings are exploratory and hypothesis-generating, highlighting the need for larger multicenter studies with prespecified methods to examine preference heterogeneity and willingness to pay.

Ying Liu, Junlin Huang, Congli Chen et al.

CNRead at source

Peer-reviewed articlePubMed (US National Library of Medicine)6 Sept 2026

Health Literacy in Pediatric Care: Evidence, Gaps, and Opportunities.

Health literacy is a foundational component of providing accessible pediatric care, influencing whether families can understand, access, and use health information. As families increasingly rely on online health resources, health literacy skills applied to digital information, or e-health literacy, has become an evolving dimension of pediatric health literacy. The concept of health literacy extends beyond an individual's abilities, intersecting with the demands placed on individuals by healthcare systems. There is a growing focus on organizational health literacy (OHL), which reflects how effectively systems support equitable communication, but this remains infrequently assessed or implemented. Limited parent, child, and adolescent health literacy is common and disproportionately affects families with lower income, minoritized racial/ethnic backgrounds, lower educational attainment, and who use languages other than English for care. Limited health literacy has been associated with decreased disease-specific knowledge, suboptimal health behaviors, and worse clinical outcomes. Although health literacy-informed strategies can improve comprehension and outcomes, best practices, such as teach-back, remain underutilized across pediatric care settings. The rapid expansion of digital tools offers new opportunities to enhance health literacy-informed communication but also introduces challenges related to equity, accuracy, and safety. Advancing pediatric health literacy requires coordinated efforts: embedding health literacy principles into institutional and national policies, integrating universal health literacy precautions into clinical workflows, expanding clinician and patient health literacy education, and advancing health literacy-focused research, including on digital interventions and artificial intelligence (AI)-supported communication. Prioritizing these efforts is essential to creating health literate-systems that enable all families to access, understand and use health information.

Alyssa Coffin, Alexander F Glick, H Shonna Yin

DevelopmentSurvivalRead at source

Peer-reviewed articlePubMed (US National Library of Medicine)14 Sept 2026

Preparing for Future Group B Streptococcus Vaccines: Perspectives of Pregnant Women in Australia.

BACKGROUND: Vaccines for Group B Streptococcus (GBS) intended for pregnant women are currently in advanced stages of clinical trials. Conducting preparatory research now can help identify factors influencing GBS vaccine acceptance and potential challenges to future implementation. METHODS: This qualitative study recruited participants nationally through social media and antenatal clinics of a maternity hospital in South Australia between December 2024 and August 2025. Eligible participants were pregnant women aged ≥18 years residing in Australia. Online interviews and focus group discussions (FGDs) were held to explore pregnant women's knowledge and perceptions of GBS, experiences with current screening and management strategies, and views on future maternal GBS vaccination. Twenty-five women participated in FGDs and six in individual interviews; FGD group sizes ranged from two to five participants. Data were analysed using inductive content analysis. RESULTS: A total of 31 pregnant women participated, aged 19-43 years. Most participants (51.6%) were from South Australia, 87.1% had tertiary education, and 51.6% were employed in the health sector. Five themes were identified: (1) infant wellbeing is the dominant driver of vaccine acceptance, (2) maternal vaccination is preferred over current antibiotic prophylaxis, (3) perceived uncertainty about vaccine safety and knowledge gaps fuel caution, (4) accessible and flexible vaccination delivery models are desired, and (5) multimodal, woman-centred communication delivered through trusted healthcare providers is required. CONCLUSIONS: Findings highlight the importance of addressing knowledge and safety concerns and incorporating accessible, flexible and woman-centred approaches into the planning of future maternal GBS vaccination programmes.

Prabha H Andraweera, Emma Jeffs, Bing Wang et al.

SurvivalDevelopmentAURead at source

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