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22,944 reports · page 2204 of 2295

Peer-reviewed articleOpenAlex - Early Childhood7 Oct 2026

Longitudinal associations between parental trauma-related symptoms and adolescent emotion regulation: a three-wave dyadic analysis

Introduction Intergenerational trauma research has often treated transmission as unidirectional and static, overlooking dyadic and reciprocal processes. This study applied a three-wave longitudinal Actor–Partner Interdependence Model (APIM) to examine bidirectional associations between parental trauma-related symptoms and adolescent emotion regulation (ER) difficulties. Methods A total of 247 parent–adolescent dyads from Syrian refugee and Jordanian host-community families in Jordan completed three waves over six months. Parents reported lifetime trauma at T1; both parents and adolescents reported ER difficulties at T1, T2, and T3. Distinguishable-dyad APIMs estimated autoregressive, actor, and partner effects with FIML and covariates. Results Parental trauma at T1 significantly predicted offspring ER difficulties at T2 (β = 0.23), mediated longitudinally by parent ER at T2. Offspring ER at T1 also predicted parent ER at T2 (β = 0.12), but this child-driven effect did not persist to T3. Refugee status did not moderate the transmission paths. Discussion Intergenerational trauma appears to operate as a dynamically co-constructed dyadic process. Findings support process-focused, dyadic interventions rather than treating adolescents in isolation.

Shooroq Mabreah, Mohammed Abu Al-Rub

DevelopmentJO

Peer-reviewed articleOpenAlex - Early Childhood7 Oct 2026

Exploring a child's representations of the sea through drawings and narratives

Early engagement with marine sustainability in early childhood education and care (ECEC) can nurture ethical awareness, shared responsibility and a sense of ecological belonging. ECEC settings offer spaces where children explore environmental questions and begin to see themselves as active participants in ecological communities whose interpretations and experiences matter. Aligned with the aspirations of Sustainable Development Goal 14, which calls for the conservation and sustainable use of oceans and marine resources, this paper situates children's drawings of the sea within contemporary debates that move beyond developmental framings. Focusing on one, six-year-old child's three interconnected drawings of the sea, this study reconceptualises drawing as a relational and multimodal act of meaning-making rather than a measure of knowledge acquisition. Drawing on social semiotic, socio-cultural and ecological theory, it examines how ecological understanding, emotion and imagination unfold in process. Data were generated through participatory, image-based methods in a Norwegian coastal ECEC setting and analysed using a reflexive thematic approach. Across the drawings, an evolving ecological narrative emerges in which interdependence, vulnerability and human disruption are explored across scale: from storms and food chains to obstruction, waste and cosmic disturbance. Power is depicted as relational and unstable; animals act and employ strategies, but remain vulnerable to environmental disruption. Human infrastructure and pollution are rendered morally consequential. Fantasy operates not as escapism but as a resource for engaging with environmental uncertainty. The study argues for recognising drawing as a dialogic space where ecological knowledge, affect and ethical positioning converge, enabling children to participate meaningfully in imagining sustainable futures.

Anne Grethe Baustad, Josephine Deguara

DevelopmentParticipationNORead at source

Peer-reviewed articleOpenAlex - Early Childhood7 Oct 2026

Longitudinal basophil activation testing for assessing response to low-dose initiation, slow-escalation peanut oral immunotherapy in patients with high Ara h 2-sIgE

Background Peanut oral immunotherapy (pOIT) can achieve desensitization, yet patients with high peanut-sIgE may experience more adverse reactions and treatment failure. We evaluated a conservative pOIT protocol in children with high Ara h 2-sIgE (≥40 kU/L) and examined longitudinal basophil activation test (BAT) and sIgE/sIgG4 trajectories as candidate biomarkers. Methods Thirty-two peanut-allergic children underwent pOIT, including 16 with high and 16 with lower Ara h 2-sIgE. All received low-dose initiation and slow up-dosing. Clinical outcomes, safety, and immunologic markers were evaluated longitudinally for up to 36 months. Results Effective desensitization (≥300 mg peanut protein) was achieved in 68.8% of high-sIgE and 62.5% of lower-sIgE participants. One severe adverse event occurred in each subgroup, with no treatment-related discontinuations. Peanut and Ara h 2/6-sIgE levels rose transiently before gradually declining, whereas sIgG4 increased early, leading to a reduced sIgE/sIgG4 ratio. A ratio <50 was associated with effective desensitization. BAT responses initially increased and subsequently declined, with progressive increase in the activation threshold. Baseline BAT and sIgE were not associated with desensitization. However, BAT area under the curve (AUC) <100 was significantly associated with effective desensitization with ROC AUC of 0.784 (bootstrap 95% CI 0.536–0.983). Exploratory time-lagged analyses did not establish prospective predictive utility. Conclusions Low-dose initiation, slow-escalation pOIT achieved effective desensitization in patients with high Ara h 2-sIgE, without treatment-related discontinuations. Longitudinal reductions in BAT and sIgE/sIgG4 ratio were associated with increased ingested dose. These exploratory biomarkers may provide adjunctive information during pOIT, but prospective validation is required.

Jinguo Chen, J. Joanna Yu, Jing Yu et al.

SurvivalPre/postUSRead at source

Peer-reviewed articleOpenAlex - Early Childhood7 Oct 2026

Reward positivity and affective functioning in early childhood: evidence from temporospatial principal components analysis

Reward-related Positivity (RewP) indexes neural sensitivity to reward feedback and has been widely studied in adolescents and adults. However, little is known about how individual differences in RewP are associated with emotional functioning during early childhood, a critical period for affective development. Interpretation of feedback-related ERPs in children is further complicated by temporally overlapping components. This study examined whether a principal component analysis (PCA)-derived RewP is associated with affective functioning in children aged 4-7 years. Electroencephalography was recorded from 140 children during an age-appropriate reward task. Temporospatial PCA was performed on the full EEG sample ( n = 140), and primary regression analyses were conducted in the subset with complete covariate data ( n = 48). Temporospatial PCA was applied to isolate a RewP component differentiating gain from loss feedback. Positive and negative affect were assessed using the child version of the Positive and Negative Affect Schedule. Regression analyses examined whether PCA-derived RewP- and gain-related P200 amplitudes were associated with affective functioning while controlling for age, sex, ethnicity, income-to-need ratio, child depressive symptoms, and parental depressive symptoms. At the group level, boys showed greater PCA-derived gain-related P200 amplitudes than girls. At the individual level, higher child positive affect was associated with larger PCA-derived RewP amplitudes in the primary covariate-adjusted regression model. In sensitivity analyses conducted in the larger sample without the income-to-needs covariate, negative affect, rather than positive affect, was significantly associated with PCA-derived RewP amplitude. These findings provide novel evidence that RewP may serve as an early neural marker of affective functioning. By extending RewP research to an understudied developmental period and emphasizing normative emotional functioning, this study advances understanding of early reward processing and highlights the utility of PCA for isolating meaningful ERP components in children.

Yu Sun Chung, Armen Bagdasarov, Michael Santo Gaffrey

DevelopmentUSRead at source

Peer-reviewed articleOpenAlex - Early Childhood7 Oct 2026

Risk factors analysis and validation of early treatment non-response in children with primary ITP: a multicenter retrospective cohort study

Objective To identify factors associated with early non-response to first-line treatment in children with primary immune thrombocytopenia (ITP), and to develop and externally validate a prediction model. Methods This multicenter retrospective cohort study included 335 children with newly diagnosed primary ITP as the derivation cohort, including 255 responders and 80 non-responders. Clinical data obtained after admission were collected. Candidate variables were screened using correlation analysis and least absolute shrinkage and selection operator (LASSO) regression, followed by multivariable logistic regression to identify factors associated with early treatment non-response. Model discrimination was evaluated using the area under the receiver operating characteristic curve (AUC). An independent external validation cohort of 78 children was additionally included to assess model discrimination. Results Among the 335 children, 255 (76.1%) achieved a treatment response within 14 days after first-line therapy, whereas 80 (23.9%) did not. Multivariable analysis showed that older age (OR = 1.769, 95% CI: 1.629–1.920, P < 0.001), higher platelet-to-lymphocyte ratio (PLR) (OR = 1.622, 95% CI: 1.112–2.367, P = 0.012), and antinuclear antibody (ANA) positivity (OR = 3.142, 95% CI: 1.626–6.071, P < 0.001) were independently associated with early treatment non-response. The combined model incorporating age, PLR, and ANA achieved an AUC of 0.831 (95% CI: 0.778–0.885) in the derivation cohort and 0.718 (95% CI: 0.591–0.845) in the independent external validation cohort. Calibration was acceptable in both cohorts, with Hosmer–Lemeshow P values of 0.609 and 0.220 and Brier scores of 0.129 and 0.137, respectively. Conclusion Older age, higher PLR, and ANA positivity were independently associated with early non-response to first-line treatment within 14 days in children with newly diagnosed primary ITP. These findings may help identify children at high risk of treatment non-response and support individualized monitoring and treatment strategies.

Mingwei Li, Mei Yan

SurvivalCNRead at source

Every report we find, newest first.

How to use the reports

Longitudinal associations between parental trauma-related symptoms and adolescent emotion regulation: a three-wave dyadic analysis

Exploring a child's representations of the sea through drawings and narratives

Families and Relationship-Based Development across Our Lifespan

Longitudinal basophil activation testing for assessing response to low-dose initiation, slow-escalation peanut oral immunotherapy in patients with high Ara h 2-sIgE

Creating nurturing environments: Addressing domestic violence to improve early childhood development outcomes

Reward positivity and affective functioning in early childhood: evidence from temporospatial principal components analysis

A contação de histórias como recurso pedagógico na educação infantil

Are childhood diseases associated with Molar-Incisor Hypomineralization? – Results from an observational study

Risk factors analysis and validation of early treatment non-response in children with primary ITP: a multicenter retrospective cohort study

Optimal Developmental Processes and Those in the Autism Profile

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