Hospital-acquired infections (HAIs) and delayed recovery from severely malnourished children during stabilization: Evidence from retrospective cohort analysis
Background: Several studies have highlighted the high impact of HAIs and their effects on pediatric recovery in Ethiopia. Objectives: This study examined the effect of hospital-acquired infections (HAIs) on the recovery of children with severe acute malnutrition (SAM). Design: A retrospective cohort study was conducted at Asella Referral and Teaching Hospital in Oromia, Ethiopia. Materials and methods: Hospital acquired infections (HAIs) defined as infections occurred within 48 hours or more after admission to the Hospital and documented by treating clinicians in medical records. Diagnosis was made using routine clinical assessment, and available laboratory findings according to the standard hospital practice. Of 635 children admitted during the study period, 142 records were excluded (not meeting SAM criteria, unacceptable age range, or incomplete data). Consequently, 493 eligible children with comprehensive documentation were included in the final study. Kaplan–Meier survival analysis was used to compare recovery times between children with and without HAIs. Time to nutritional recovery (in days), defined as the length of hospital stay until recovery, and compared between children with and without hospital-acquired infections. Results: Children without hospital-acquired infections had a higher probability of recovery over time compared to those with HAIs (log-rank test, p < 0.001). Factors significantly associated with HAIs included rural residence, incomplete immunization, and nasogastric tube feeding. Conclusions: Hospital-acquired infections are a common complication among children admitted with severe acute malnutrition and are associated with slower recovery and prolonged hospital stay. Improving child survival requires an integrated approach that strengthens infection prevention and control (IPC), ensures reliable WASH infrastructure, and promotes safe feeding and hygiene practices in therapeutic feeding units. Addressing these structural and procedural gaps is essential to achieving sustainable improvements in nutrition recovery and infection control in Ethiopian hospitals.