Evidence

Evidence on children's well-being, problem first.

Every finding is tied to a defined problem for children, the intervention that claims to solve it, and its type of design. Open any card to compare the same intervention across countries.

152 evidence items · page 11 of 13

Survival

Problem

Stunting (impaired linear growth) among children under five

Intervention: Red ginger extract gummy candy given as a functional food for one month, compared with a placebo
Population: Children under five years old in Indonesia

Key finding

Height increased significantly within the intervention group (p=0.005).

Experimental

Heryani et al. · OpenAlex · 30 Sept 2026

Survival

Problem

Stunting among children in villages of Lamongan Regency, Indonesia

Intervention: Allocation of Village Fund money to health, used for stunting reduction programmes
Population: Villages in Lamongan Regency, Indonesia, using village-level data for 2023-2024

Key finding

PSM: about 1.2 percentage points lower stunting prevalence in villages receiving the intervention than in non-treated villages (statistically significant).

Practitioner

Rakhimah et al. · OpenAlex · 30 Sept 2026

Survival

Problem

Poor infant and young child feeding practices contributing to child stunting in Nigeria

Intervention: Accelerating Nutrition Results in Nigeria (ANRiN) project, a nutrition intervention for mothers and young children
Population: 503 mothers of children aged 6–23 months in Plateau State, Nigeria, both ANRiN beneficiaries and non-beneficiaries

Key finding

Practice scores were higher among beneficiaries (6.95 ± 1.42 vs. 6.34 ± 1.57, p < 0.001).

Practitioner

Osoteku et al. · OpenAlex · 30 Sept 2026

Survival

Problem

Microbiological diagnosis of pulmonary tuberculosis in children is difficult, especially in infants, malnourished children and children living with HIV.

Intervention: Testing induced sputum with Xpert MTB/RIF Ultra, alongside liquid culture.
Population: 636 children under 15 years investigated for pulmonary TB at Dora Nginza Hospital, South Africa, including infants, underweight children and children living with HIV.

Key finding

Ultra sensitivity was 90.9% (95%CI 82.9-96.0) and specificity 89.6% (95%CI 86.7-92.0).

Practitioner

Luiz et al. · OpenAlex · 1 Oct 2026

Survival

Problem

Disseminated BCG disease after vaccination in infants with primary immunodeficiency, where linezolid is limited by bone marrow suppression

Intervention: Contezolid-containing multidrug antimycobacterial regimens combined with hematopoietic stem cell transplantation
Population: Three infants aged 3–9.5 months with primary immunodeficiency in China (Wiskott–Aldrich syndrome, X-linked SCID, IL-12 receptor β1 deficiency)

Key finding

All three patients achieved satisfactory clinical resolution of infectious lesions after 11–12 months of treatment.

Practitioner

Zhang et al. · OpenAlex · 2 Oct 2026

Survival

Problem

Poorer feeding, growth, longer hospitalization, and neurodevelopmental and parental psychological outcomes in preterm or low-birth-weight infants

Intervention: Parent-administered massage alone or combined with tactile, kinesthetic, oral or other developmental sensory components, compared with routine care or non-massage controls
Population: Preterm or low-birth-weight infants and their parents, across 24 randomized controlled trials

Key finding

Breastfeeding or human-milk feeding at discharge: OR 5.42 (95% CI 2.44–11.94), moderate certainty.

Experimental

Li et al. · OpenAlex · 2 Oct 2026

Development

Problem

Limited physical fitness and psychosocial adaptation (self-esteem, well-being, social functioning) in school-age children

Intervention: School-based physical activity programmes lasting at least 8 weeks
Population: Children aged 6 to 12 years in 40 studies, 21,793 participants in total

Key finding

Cardiorespiratory fitness: g = 0.36 (95% CI 0.25 to 0.46), I2 = 98%

Experimental

Zhang et al. · OpenAlex · 2 Oct 2026

Survival

EGYE

Problem

Preeclampsia in high-risk pregnancies, a leading cause of maternal and neonatal illness and death

Intervention: Statins, metformin, or vitamin D (at different doses, alone or combined with omega-3) given to pregnant women, compared with placebo
Population: High-risk pregnant women (4,078 across eight randomised trials)

Key finding

Vitamin D 4,000 IU/day: risk ratio 0.21 (95% CI 0.06-0.72) for preeclampsia versus placebo, roughly an 8% absolute risk difference.

Experimental

El-Khouly et al. · OpenAlex · 2 Oct 2026

Participation

Problem

Violence against children, including maltreatment, bullying, youth violence, intimate partner violence, and sexual violence, in Sub-Saharan Africa

Intervention: A range of violence-prevention programs targeting economic strengthening, teachers/schools, whole families, caregivers only, or children only
Population: Children in Sub-Saharan Africa

Key finding

Programs focused on economic strengthening, teachers/schools, entire families, caregivers only, and children only were generally effective in reducing violence against children

Experimental

Edwards et al. · OpenAlex · 25 Mar 2023

Protection

Problem

Child marriage of girls before age 18 in sub-Saharan Africa

Intervention: Presence of an older sister (versus an older brother) as a family structure factor
Population: Girls in sub-Saharan Africa with an older sibling

Key finding

Reduces likelihood of marrying before age 18 by 1.5 percent

Practitioner

Asker et al. · Crossref · 1 Jan 2025

Development

Problem

Psychological and emotional challenges (anxiety, low motivation, reduced concentration) among students from broken homes affecting their academic performance

Intervention: Islamic Education value-based teaching (tawakkal, patience, sincerity, character formation) and teacher emotional/moral support
Population: Primary and secondary school students from broken home backgrounds

Key finding

Islamic values help students reinterpret family experiences positively and turn adversity into motivation.

Practitioner

Wafa et al. · OpenAlex · 21 Sept 2026

Survival

Problem

Parental hesitancy toward childhood vaccination in Nigeria, contributing to preventable illness and death.

Intervention: Various health communication strategies aimed at reducing parental vaccine hesitancy, including media campaigns, government messaging, community-based engagement, and phone-based messaging.
Population: Parents, carers, or primary caregivers of children aged 0-3 years in Nigeria

Key finding

Media campaign strategies were identified as one approach to address hesitancy.

Practitioner

Ike et al. · OpenAlex · 25 Aug 2026

Evidence on children's well-being, problem first.

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Evidence on children's well-being, problem first.