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The problem
Intervention: Standard cancer treatment and pregnancy management for young female cancer survivors
Who it was tested with: 19,474 children born to female cancer survivors under age 40 in South Korea, matched with 58,422 controls born to women without cancer history.
Children or communities are compared with a group that did not receive the intervention, or followed over years. This is the design that best separates what the intervention did from everything else that changed.
"Using nationwide retrospective data from the Korean National Health Insurance Service between January 1, 2005, and December 31, 2019, we included 19,474 children born to female cancer survivors under 40 years old. Propensity-score matching (1:3) with 58,422 controls born to women without cancer was conducted." This represents a quasi-experimental design using propensity-score matching to create comparable groups, allowing estimation of the association between maternal cancer history and child neurodevelopmental outcomes.
Observational design cannot establish causation. Health insurance data may not capture all NDDs or severity. Cannot determine which cancer treatments or maternal factors drive the increased risk.
Across countries and designs
1 study · 1 country
