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The problem
Intervention: Vaccination against Bordetella pertussis (including recommended third trimester maternal vaccination) and strengthened immunisation programmes
Who it was tested with: Infants and young children, particularly those under 3 months, in a South African PICU setting.
Experience from people who deliver programmes: stories, case studies and lessons learned. Valuable for understanding how and why, and for spotting what to test next, but not a measure of effect.
"This study describes the clinical profile, morbidity, mortality and management of children with critical pertussis admitted to a South African paediatric intensive care unit (PICU)" through "a retrospective analysis of children with critical pertussis admitted to the PICU over 1 year." The study documents the burden of unimmunised critical pertussis cases and advocates for vaccination, though it does not evaluate a specific vaccination intervention as evidence of its effectiveness.
This is a retrospective case series without a comparison group or intervention evaluation. The small sample size and single-centre setting limit generalizability. No independent predictors of mortality were identified, suggesting the relationship between risk factors and outcomes is complex.
Across countries and designs
1 study · 1 country
