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The problem
Intervention: Maternal-infant nicotinamide intervention targeting stunting
Who it was tested with: Infants born in rural Tanzania at different times of year, from the ELICIT trial cohort.
Experience from people who deliver programmes: stories, case studies and lessons learned. Valuable for understanding how and why, and for spotting what to test next, but not a measure of effect.
"Urinary and plasma metabolites in Tanzanian infants follow seasonal waveforms dependent upon their month of birth, persisting up to at least 18 months of life, which were related to food insecurity, breastmilk composition and rainfall." The study demonstrates that birth season shapes infant metabolic profiles in ways that persist and affect intervention responses, though the mechanisms linking seasonal environmental pressures to these metabolic and developmental outcomes require further investigation.
Secondary analysis with explorative focus; causality not established; seasonal patterns specific to Tanzania; mechanisms not fully determined
Across countries and designs
1 study · 1 country
