Search reports, ask a question, or jump to a page.
The problem
Intervention: Single 2g oral dose of azithromycin administered intrapartum to pregnant women in labour
Who it was tested with: Pregnant patients ≥28 weeks gestation (singleton or multiple gestation) presenting in labour for planned vaginal delivery in multiple international sites.
Children or communities are compared with a group that did not receive the intervention, or followed over years. This is the design that best separates what the intervention did from everything else that changed.
"The estimated relative risks (and 95% confidence interval) of any maternal or neonatal infection comparing azithromycin to placebo were obtained by fitting a Poisson model adjusting for site, treatment arm, hours between drug administration and delivery (as continuous measure, and ≤ 12 or > 12 h for maternal and ≤ 9 or > 9 h for neonatal), and the two-way interaction between treatment arm and hours between drug administration and delivery." The analysis used a randomized controlled trial design with statistical interaction testing to determine whether the protective effect of azithromycin varied according to the time interval between drug administration and delivery.
Secondary analysis of existing trial data; does not clarify mechanisms for lack of neonatal benefit; cannot fully explain regional variation; limited ability to assess longer-term outcomes or adverse effects
Across countries and designs
1 study · 0 countries
Classified by the Hub's AI
Not yet reviewed by a person. Model output is not AICS's view until reviewed.
claude-haiku-4-5-20251001 · synth-v1
