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The problem
Intervention: Antipsychotic medications (aripiprazole, asenapine, lurasidone, olanzapine, paliperidone, quetiapine, risperidone, and ziprasidone) versus placebo
Who it was tested with: Children and adolescents with schizophrenia (2,271 patients across 10 trials).
Children or communities are compared with a group that did not receive the intervention, or followed over years. This is the design that best separates what the intervention did from everything else that changed.
"We conducted systematic review and meta-analysis of randomized placebo-controlled trials (RCTs) assessing efficacy and adverse effects of APs in acute childhood and adolescent schizophrenia to compare clinical benefits and harms." This is an experimental design using randomised controlled trials with comparison to placebo, representing the highest evidence tier for intervention evaluation.
Mean intervention duration was only 6.4 weeks (range 6-8 weeks), so long-term effectiveness and harms are unknown. Study selection and quality assessment criteria are not detailed in the abstract. Countries of origin of included studies are not specified.
Across countries and designs
1 study · 0 countries
