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The problem
Intervention: Hepatitis B vaccination with 3-dose schedule; comparison of outcomes by age at first dose and intervals between doses
Who it was tested with: 5,485 individuals born to hepatitis B negative mothers, vaccinated with 3-dose schedule between 2-12 months of age, followed up at age 18-24 years.
Experience from people who deliver programmes: stories, case studies and lessons learned. Valuable for understanding how and why, and for spotting what to test next, but not a measure of effect.
"Data on age, sex and date of administration were collected... age at enrolment 18-24 years; age at 1st dose 2-12 months... A logistic regression was performed, adjusting for sex, follow-up time and date of 1st dose and analysis." The study is a prospective longitudinal follow-up comparing vaccination timing within a cohort measured at a single endpoint, with regression analysis to control for confounders, making it a controlled observational study meeting experimental tier criteria.
Observational design without randomisation; does not measure clinical protection or actual infection outcomes; titre <10 IU/l presence does not confirm lack of protection; results may be population-specific and require consideration with local HBV epidemiology
Across countries and designs
1 study · 0 countries
A reviewer checked the classification against the source.
claude-haiku-4-5-20251001 · synth-v1
