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The problem
Intervention: Assessment of neighborhood-level social drivers of health (measured by Childhood Opportunity Index) and their association with neurocognitive outcomes
Who it was tested with: 90 children and adolescents with sickle cell disease, mean age 7.7 years, English-fluent, without history of overt stroke or moyamoya.
The same group is measured before the intervention and again afterwards, with a baseline and an endline and sometimes a midline. Change is visible, but other causes cannot be ruled out.
"We conducted a retrospective cohort study of children and adolescents with SCD who completed standardized neurocognitive screening between January 2023 and May 2025," with neighborhood-level social drivers measured using the Childhood Opportunity Index. The study demonstrates associations between community-level opportunity and cognitive outcomes, supporting the role of social determinants in neurocognitive health.
Retrospective design without comparison group limits causal inference; cross-sectional analysis does not establish temporal relationships; participant selection limited to English-fluent children without prior stroke history
Across countries and designs
1 study · 1 country
