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The problem
Intervention: 5-step milk ladder (5-ML) and 4-step egg ladder (4-EL) protocols with supervised oral food challenges followed by home-based reintroduction of baked products
Who it was tested with: 29 children with IgE-mediated CMA and/or HEA, classified as 'high risk' due to history of severe allergic symptoms and/or asthma and/or elevated specific IgE levels.
Experience from people who deliver programmes: stories, case studies and lessons learned. Valuable for understanding how and why, and for spotting what to test next, but not a measure of effect.
"Tolerance acquisition to baked products was assessed via open-label supervised oral food challenges (OFCs), subsequent steps of the food ladders were performed in the majority through home-based reintroduction." The study demonstrates that a structured, stepped introduction protocol with medical supervision can achieve tolerance in high-risk children, though the lack of a control group limits causal inference.
Small sample size without a comparison group; open-label design without blinding; no randomisation; home-based reintroduction not formally monitored; limited follow-up period reported
Across countries and designs
2 studies · 2 countries
