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The problem
Intervention: Co-administration of the same vaccines (given simultaneously) versus separate administration (given at different times)
Who it was tested with: Children aged 0-18 years receiving routine vaccinations.
Experience from people who deliver programmes: stories, case studies and lessons learned. Valuable for understanding how and why, and for spotting what to test next, but not a measure of effect.
"Fifty studies compared co-administered vaccines versus the same vaccines administered separately." The review systematically identified and synthesized evidence from comparative studies examining the safety outcome of interest, though the inconclusive finding reflects the limited quality and heterogeneity of the evidence base rather than clear evidence of harm or safety.
One-third of included studies lacked statistical assessment of adverse events; brief safety descriptions were common; heterogeneity in study designs and reporting made synthesis difficult; paucity of large post-licensure studies; no meta-analysis performed due to study quality and heterogeneity.
Across countries and designs
1 study · 1 country
