Search reports, ask a question, or jump to a page.
The problem
Intervention: Vaccination of children aged 9 months to <16 years with typhoid conjugate vaccine (TCV)
Who it was tested with: Children aged 9 months to <16 years in Dhaka, Bangladesh; unvaccinated household and school members of all ages.
Children or communities are compared with a group that did not receive the intervention, or followed over years. This is the design that best separates what the intervention did from everything else that changed.
"For this study, 150 geographical clusters were randomly assigned to receive TCV or Japanese encephalitis (JE) vaccine. Children aged 9 months to <16 years were vaccinated. Household-level herd protection was estimated by indirect vaccine effectiveness (iVE), comparing typhoid incidence among residents of all ages who did not receive the assigned study vaccine in TCV clusters with those in JE clusters." This is a cluster-randomised controlled design comparing outcomes in vaccinated and control clusters, meeting the EXPERIMENTAL tier standard.
Estimates were imprecise with very wide confidence intervals, making it difficult to draw firm conclusions. The study was a secondary analysis not specifically designed to measure herd protection. School-level coverage varied widely (8%-55%), and the sample size for some analyses was small.
Across countries and designs
2 studies · 2 countries
