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The problem
Intervention: Three-armed comparison of standard care (no oxygen), low-flow nasal cannula oxygen, and high-flow nasal cannula oxygen for children with pneumonia and SpO2 of 90-93%
Who it was tested with: Children aged 1-59 months with WHO-defined pneumonia and peripheral arterial haemoglobin oxygen saturation of 90-93% at Salima District Hospital, Malawi.
Children or communities are compared with a group that did not receive the intervention, or followed over years. This is the design that best separates what the intervention did from everything else that changed.
"Pilot, open-label, three-armed randomised control trial" - the study was designed as a randomised controlled trial to test feasibility of comparing the three oxygen approaches, establishing the foundation for a future effectiveness trial.
This is a pilot feasibility study designed to test whether a larger trial is possible, not to evaluate effectiveness of the three interventions. The small sample size and open-label design cannot establish which oxygen approach is superior. Treatment failure rates are reported for all arms combined without comparison between arms.
Across countries and designs
1 study · 1 country
