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The problem
Intervention: Acute pharmacological treatments for migraine including ibuprofen, sumatriptan/naproxen sodium, zolmitriptan, rizatriptan, dihydroergotamine, and other medications compared with placebo
Who it was tested with: Children and adolescents with migraine (8,914 participants across 30 studies).
Children or communities are compared with a group that did not receive the intervention, or followed over years. This is the design that best separates what the intervention did from everything else that changed.
"Double-blind randomized clinical trials evaluating the currently available acute treatments for childhood and adolescent migraines were included." This represents a high-quality synthesis of experimental evidence comparing multiple pharmacological interventions with placebo and each other in a controlled setting.
The analysis was restricted to published English-language studies. High-quality evidence for some medications like dihydroergotamine was limited. None of the drugs significantly reduced rescue medication use, suggesting limited sustained efficacy.
Across countries and designs
1 study · 0 countries
Not yet reviewed by a person. Model output is not AICS's view until reviewed.
claude-haiku-4-5-20251001 · synth-v1
