Search reports, ask a question, or jump to a page.
The problem
Intervention: Measurement and analysis of aflatoxin exposure through blood biomarkers in relation to longitudinal growth monitoring
Who it was tested with: 1,675 mother-infant dyads in rural Nepal, followed from pregnancy to 2 years of age (2015-2019).
Children or communities are compared with a group that did not receive the intervention, or followed over years. This is the design that best separates what the intervention did from everything else that changed.
"We conducted a longitudinal birth cohort study involving 1675 mother-infant dyads in rural Nepal. Participants were repeatedly visited from pregnancy to 2 years of age (2015-2019). One blood sample was collected during pregnancy and 4 samples were collected from the children at 3, 6, 12, and 18-22 months of age to measure concentrations of aflatoxin B1 (AFB1)-lysine adduct. Multivariate linear fixed-effects and logistic models with generalized estimating equations were used to identify associations between child growth and aflatoxin exposure." This prospective longitudinal design with repeated measurements and multivariate analysis provides evidence that chronic aflatoxin exposure is associated with impaired child growth, though causation cannot be definitively established.
Observational study design cannot prove causation. Unmeasured confounders related to diet quality, sanitation, or other environmental exposures may explain some associations. Specific food sources of aflatoxin exposure were not identified.
Across countries and designs
1 study · 1 country
