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The problem
Intervention: Recombinant growth hormone (rGH) therapy at standard doses
Who it was tested with: 77 prepubertal children with molecularly proven Silver-Russell syndrome.
Experience from people who deliver programmes: stories, case studies and lessons learned. Valuable for understanding how and why, and for spotting what to test next, but not a measure of effect.
"Retrospective monocentric data of growth and nutritional characteristics of 77 prepubertal children with molecularly proven SRS during the first 2 years of rGH therapy were analyzed." This is a pre-post design measuring the same children before and after treatment initiation, with baseline and 2-year follow-up measurements.
Retrospective design with no control group; single center data; only short-term follow-up (2 years); no assessment of long-term outcomes or adverse effects
Across countries and designs
2 studies · 1 country
