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The problem
Intervention: Tdap (tetanus, diphtheria, and acellular pertussis) vaccination of pregnant and non-pregnant women
Who it was tested with: 30 non-pregnant women and 156 pregnant women in Guatemala.
The same group is measured before the intervention and again afterwards, with a baseline and an endline and sometimes a midline. Change is visible, but other causes cannot be ruled out.
"We compared antibody responses to Tdap between 30 non-pregnant women and 156 pregnant women enrolled in a clinical trial of maternal Tdap vaccination in Guatemala. Pre-vaccination antibody concentrations among both groups were similar for all vaccine antigens. At 2 months post-vaccination, antibody concentrations against vaccine antigens increased in both groups and were higher among non-pregnant women. By 9 months, antibody concentrations had decayed and were no longer different by study group." The study tracks the same groups over time with measurements at multiple time points, showing that pregnancy affects the initial immune response but this difference diminishes over time.
The study measures immunogenicity (antibody response) rather than clinical protection or disease outcomes. Comparison group size was unbalanced (30 non-pregnant vs 156 pregnant women). Limited to a single country setting.
Across countries and designs
1 study · 1 country
