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The problem
Intervention: Supportive care including wound care, antibiotics, nasogastric feeding, bladder catheterization, sedation with diazepam and chlorpromazine, and delayed tetanus immunoglobulin administration
Who it was tested with: One 9-year-old African boy with generalized tetanus (Grade 3 severity).
Experience from people who deliver programmes: stories, case studies and lessons learned. Valuable for understanding how and why, and for spotting what to test next, but not a measure of effect.
"He was managed on the general paediatric ward in a dark, quiet room without access to intensive care. He was hospitalized for 25 days and his treatment included wound care, antibiotics, nasogastric feeding, bladder catheterization, and alternating sedation with diazepam and chlorpromazine. The child recovered and was discharged alive." This demonstrates that comprehensive supportive care in resource-limited settings can achieve survival from severe tetanus, though the case design cannot isolate which components were essential.
Single case report with no comparison group or control; cannot establish causation or generalizability; unclear which specific interventions were most critical to survival; potential for publication bias towards positive outcomes
Across countries and designs
1 study · 1 country
