Peer-reviewed article
Gender-neutral prevention: HPV vaccination willingness and related cancer awareness among Chinese parents of boys and girls.
Jiaqi Zhu, Chenggang Xing, Yu Kong, Jieying Li, Wei Shang et al. ·
Summary
Written by AI, not yet AICS's view · claude-haiku-4-5-20251001This study surveyed 1,041 parents in Shandong Province, China to understand their awareness of HPV vaccination and willingness to vaccinate their children following approval of HPV vaccination for boys in January 2025. While 71.3% of parents were aware of HPV vaccination for girls, only 35.73% knew about the new program for boys. After receiving information about the vaccine, 62% intended to vaccinate their child, but parents of sons were significantly less willing than parents of daughters. The study identifies knowledge gaps and gender-based barriers as major obstacles to achieving gender-neutral HPV vaccination coverage.
Key points
- 71.3% of parents were aware of HPV vaccination for girls, compared to only 35.73% aware of the newly approved program for boys
- After receiving vaccine information, 62% of parents expressed intention to vaccinate their child, 10% declined, and 28% remained undecided
- Parents of daughters had significantly higher vaccination intent than parents of sons (OR = 0.110, 95% CI: 0.077-0.157, p = 5.3 × 10-34)
- Key determinants influencing parental decisions included perceived health risks, vaccine efficacy beliefs, trust in healthcare providers, and child's gender
- Significant knowledge gaps remain regarding HPV and HPV-associated oropharyngeal cancer among Chinese parents
Limitations
The study was conducted in Shandong Province only, which may not represent all regions of China. The cross-sectional design captures a single point in time and cannot determine causal relationships or track changes in parental attitudes over time.
Abstract
Following the approval of human papillomavirus (HPV) vaccination for males in China in January 2025, this study aimed to investigate parental knowledge of HPV, willingness to recommend HPV vaccination for their children, and associated determinants. The study also assessed parental awareness of HPV-associated oropharyngeal cancer (OPC) among parents of minor boys and girls in China. A cross-sectional online survey of parents in Shandong Province conducted from February to March 2025 yielded 1251 submissions, with 1041 valid questionnaires retained after applying prespecified exclusion criteria (refer to flowchart). Data were collected using anonymous self-administered questionnaires that covered demographic characteristics, knowledge of HPV, attitudes toward vaccination, vaccination intentions, and perceived barriers. Among the 1041 parents who completed the survey, 71.3% were aware of HPV and the vaccination program for girls, while only 35.73% were aware of the newly approved program for boys. After receiving information about the vaccine, 62% expressed an intention to vaccinate their child, 10% declined, and 28% remained undecided. Parents of daughters demonstrated significantly higher vaccination intent compared to parents of sons (OR = 0.110, 95% CI: 0.077-0.157, p = 5.3 × 10-34), indicating that the odds of intending to vaccinate were significantly lower for parents of boys. Key determinants influencing parental decisions included perceived health risks, beliefs about vaccine efficacy, trust in healthcare provider recommendations, and the child's gender, which were identified as significant determinants influencing parental HPV vaccination decisions. Significant knowledge gaps remain among Chinese parents regarding HPV and HPV-associated OPC. Public health initiatives are urgently needed to enhance parental understanding of HPV vaccination benefits, including its extension to boys, and to elucidate the risks of HPV-associated OPC. The implementation of a gender-neutral HPV vaccination policy faces substantial challenges rooted in awareness and gender norms. It is imperative to address these barriers through targeted health education, systematic training of healthcare professionals, and robust policy support. By dismantling gendered perceptions of health, we can achieve the overarching goal of comprehensive HPV prevention for all. Addressing these knowledge deficits and mitigating barriers to vaccine uptake are critical public health priorities.
Findings the Hub has extracted
Each claim below is labelled by its type of design and links back to this report.
- Intervention
- Provision of information about HPV vaccination benefits and HPV-associated cancer risks to parents
- Population
- Parents of minor boys and girls in Shandong Province, China (n=1,041)
Key finding
62% of parents expressed intention to vaccinate their child after receiving information