Peer-reviewed article

AI-enabled and comparator digital interventions for adolescent mental health (2020-2025): early detection, human-AI collaboration, and ethical governance-a PRISMA-ScR scoping review.

Noorayisahbe Mohd Yaacob, Mohamed Doheir, Ali Algumaei, Mohammed Nasser Al-Andoli, Jamil Abedalrahim Jamil Alsayaydeh et al. · 28 Sept 2026

Abstract

INTRODUCTION: Mental health difficulties among adolescents and youth (ages 10-24) are increasing globally, yet early intervention remains impeded by stigma, service shortages, and cultural barriers. AI-enabled technologies including chatbots, automated screening tools, and machine learning-based predictive models have been proposed as scalable approaches to address these gaps, alongside non-AI digital interventions such as therapist-guided internet-delivered cognitive behavioral therapy (iCBT) and smartphone-based CBT applications, which are examined as comparator evidence given their stronger controlled-design evidence base. METHODS: This scoping review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) reporting guidelines and Joanna Briggs Institute (JBI) methodology. A systematic database search across six databases (PubMed, Scopus, ProQuest, SpringerLink, Web of Science, and ScienceDirect), supplemented by manual and forward-citation searching, yielded 10,962 records, of which 19 studies met the predefined inclusion criteria. A Human-AI Collaboration Role framework comprising a four-level continuum from fully human-led to fully automated delivery was applied as a predefined coding dimension across all included studies. RESULTS: Most studies focused on depression and anxiety among mid-to-late adolescents in high-income countries (68.4%). Therapist-guided iCBT was the most rigorously studied format using randomized and controlled designs; AI chatbots, predictive models, and large language model (LLM)-based systems demonstrated feasibility or engagement outcomes in a limited number of studies and contexts, though randomized diagnostic chatbot trials specifically remain absent for participants under 18 years; at least one randomized non-diagnostic chatbot trial (a body-image intervention) has been conducted in this age group. Equity-related reporting was inconsistent: socioeconomic status was reported in only 10.5% of studies and cultural adaptation in 42.1%; restriction to English-language publications may further underrepresent non-Western and low- and middle-income-country evidence relevant to these equity findings. Key implementation challenges included inconsistent safeguarding protocols for minors, algorithmic bias, data privacy concerns, and insufficient integration with clinical and educational systems. DISCUSSION: The evidence base remains preliminary and methodologically heterogeneous, insufficient to support conclusions about clinical effectiveness or generalizability to diverse adolescent populations. These findings represent a descriptive map of the current evidence landscape rather than an assessment of effectiveness. Future research should prioritize adequately powered adolescent-focused trials, participatory co-design approaches, culturally informed adaptations, and transparent ethical governance frameworks to ensure responsible development of AI-enabled digital mental health tools for youth. Because the included studies were heterogeneous and no formal risk-of-bias assessment was undertaken, this review does not establish comparative clinical effectiveness, safety, or superiority of AI-enabled interventions. SYSTEMATIC REVIEW REGISTRATION: https://osf.io/sbpk2, doi: 10.17605/OSF.IO/SBPK2.