Peer-reviewed article
PRECISE-DYAD: a prospective cohort study linking maternal and infant health trajectories in sub-Saharan Africa.
Volvert ML, Wilson M, Owino RO, Blencowe H, Koech A et al. ·
Summary
Written by AI, not yet AICS's view · claude-haiku-4-5-20251001PRECISE-DYAD is a prospective cohort study following mother-child pairs in Kenya and The Gambia for the first 3 years of life to understand how pregnancy complications affect child health and development and maternal well-being. The study enrolled 2,980 women and 2,909 children between 2021 and 2024, collecting clinical data, biological samples, and developmental assessments at regular intervals. Researchers are investigating how placenta-related complications, environmental exposures like nutrition and air quality, and social factors shape maternal and child outcomes. The study includes measurement of child neurodevelopment, growth, and home environment quality, alongside maternal health, mental health, and healthcare experiences.
Key points
- 2,980 women and 2,909 children completed at least one study visit across Kenya and The Gambia
- Biorepository contains 108,897 biological samples from mothers and children
- Study examines effects of placenta-related complications (pregnancy hypertension, fetal growth restriction, preterm birth) on child health and maternal well-being
- Child assessments include neurodevelopmental assessments, home environment evaluation, and quality of life measures
- Data collection includes anthropometry, diet, cardiology assessment for mothers, mental health, healthcare costs, and environmental exposures (air and water quality)
Limitations
This document is a study protocol and baseline description rather than results, so it cannot yet tell us whether the hypothesised relationships between pregnancy complications and child outcomes actually exist or what magnitude of effects they have. Future analyses are still planned.
Abstract
Purpose The PREgnancy Care Integrating Translational Science, Everywhere (PRECISE)-DYAD Study is a prospective observational cohort designed to investigate health outcomes among mother-child pairs (dyads) over the first 3 years of life in two contexts from sub-Saharan Africa. The primary objective of the study was to explore the effects of selected placenta-related complications, such as pregnancy hypertension, fetal growth restriction and preterm birth, on (1) Child health and development, and (2) Women's health and well-being, including outcomes after stillbirth. Participants The PRECISE-DYAD Study enrolled women (and their children) originally recruited into the PRECISE pregnancy cohort study in The Gambia and Kenya between July 2021 and April 2024. Participants were seen at 6 weeks to 6 months, 12 months, 24 months and 36 months postpartum. Clinical and health data, including anthropometry and diet, were collected for both mothers and children. Mother assessment included a cardiology assessment and collection of data about symptoms of COVID-19 infection. In a subset of participants, mothers were asked about their mental health, their healthcare costs during and after pregnancy, and experiences of care during labour and childbirth/delivery. Additionally, a personal environmental exposure assessment was performed for a subset of the cohort by collecting air and water quality data alongside geographical, demographic and behavioural factors. Child development was assessed using neurodevelopmental assessments, home environment evaluation and quality of life measures. Biological samples were collected from mothers and children, processed promptly and biobanked locally. Sample data were entered into an OpenSpecimen database and linked to each individual, as well as to their corresponding social determinants and clinical data. Findings to date A total of 2980 women and 2909 children completed at least one PRECISE-DYAD Study visit. The biorepository contains 108 897 biological samples from mothers and children. Baseline descriptive analysis of the cohort is reported here. Future plans Analysis of data and samples will include biomarker studies, social determinants of health and epidemiological investigations. These analyses will explore how placenta-related complications and environmental exposures, such as nutrition and air quality, interact to shape maternal health, mental well-being, subsequent pregnancies and mother-child interaction, as well as child growth and neurodevelopment through early childhood. Additional work will examine the biological pathways linking these exposures to outcomes and the impacts of caring for children with moderate-to-severe disabilities on maternal well-being. Findings will be disseminated through scientific publications, conference presentations, engagement with local stakeholders and continued community outreach.