Project report
OTHR-02. MULTIMODALITY TREATMENT FOR CHILDREN WITH CENTRAL NERVOUS SYSTEM (CNS) TUMOR IN OUR INSTITUTE
Sasano M, Sumi K, Moro N, Oshima H, Hirai M et al. ·
Summary
Written by AI, not yet AICS's view · claude-haiku-4-5-20251001This report describes outcomes of multimodality treatment (surgery, chemotherapy, and radiation therapy) for 29 children under 15 years old with central nervous system tumors treated between 2001 and 2019. Of the 29 patients, 15 survived (11 able to walk, 3 wheelchair-dependent, 1 bedridden) and 12 died, with a mean follow-up of 66 months. The institute established a multidisciplinary team in 2016 to coordinate complex treatment plans and address quality-of-life issues including fertility and palliative care.
Key points
- 29 children with CNS tumors underwent 43 total surgeries, with mean age at first surgery 7.4 years
- 15 of 29 patients survived to follow-up; 12 deaths and 2 lost to follow-up occurred
- 22 of 29 patients received both chemotherapy and radiation therapy in addition to surgery
- A multidisciplinary medical team was established in March 2016 to coordinate treatment and manage complications
- Survivors had varying functional outcomes: 11 ambulant, 3 wheelchair-dependent, 1 bedridden
Limitations
This is a small retrospective case series from a single institution with no comparison group, so it cannot establish causality or compare treatment approaches. The report does not provide survival rates by tumor type, detail specific complications from treatment, or quantify quality-of-life outcomes.
Abstract
Abstract BACKGROUND The brain tumor has a highest mortality rate among childhood malignant tumors. Development of peripheral blood stem cell transplant combined chemotherapy and radiation therapy improved the survival rate of patients with pediatric brain tumor drastically late years. Because of its complicated treatment plan, neurosurgeons cannot readily manage these aggressive therapies which require minute whole body control including prevention of lethal infection due to bone marrow suppression. Even if such treatment is effective and patient survives, the aftereffects may reduce patient’s QOL. PURPOSE We report outcomes of the patients with CNS tumor after multimodality treatment. In addition, we introduce the activity contents by the in-hospital children brain tumor multi-disciplinary medical treatment team organized in March 2016. METHODS We retrospectively reviewed 29 patients (under 15 years old) diagnosed as CNS tumors with total of 43 tumor surgeries between January 2001 and December 2019. RESULTS The histopathological diagnoses were 7 germ cell tumor, 7 astrocytic tumor, 4 ependymal tumor, 4 medulloblastoma, 2 craniopharyngioma, 2 AT/RT and 3 others. The mean age at first surgery was 7.4 y.o. (range: 0.3–14.8). Both chemotherapy and radiation therapy were performed in 22 cases out of 29. There were 15 survivors (11 ambulant, 3 W/C, 1 bedridden), 12 deaths, 2 lost follow-ups. Mean follow-up period was 66 months (range: 1–206). CONCLUSION To improve outcomes, we hold on a regular basis of team meeting, discuss treatment plan, and share information. Recently, we also care issues of the patients, such as fertility and palliative medicine.
Findings the Hub has extracted
Each claim below is labelled by its type of design and links back to this report.
- Intervention
- Multimodality treatment including neurosurgery, chemotherapy, radiation therapy, and multidisciplinary team coordination with attention to palliative care and fertility issues
- Population
- 29 children under 15 years old diagnosed with CNS tumors between 2001 and 2019
Key finding
52% survival rate (15 of 29 survivors)
M et al. · PubMed Central (PMC) · 1 Dec 2020