Evidence

Evidence on children's well-being, problem first.

Every finding is tied to a defined problem for children, the intervention that claims to solve it, and its type of design. Open any card to compare the same intervention across countries.

89 evidence items · page 7 of 8

Survival

Problem

Low HPV vaccine uptake and completion among adolescent girls living with HIV in urban Uganda

Intervention: A quality improvement pilot program to strengthen HPV vaccination access and awareness within HIV care and treatment centres, including education and integration of vaccination services
Population: 371 adolescent girls living with HIV attending two urban HIV treatment centres in Kampala, Uganda

Key finding

Vaccine awareness was low at baseline (37%)

Practitioner

Malande et al. · OpenAlex · 31 Aug 2026

Survival

Problem

High maternal mortality and low access to antenatal care and skilled birth attendance in remote Somali communities

Intervention: Training female community health workers to provide reproductive health education, basic maternal care and referrals through the Marwo Caafimaad programme
Population: Mothers and female community health workers in 7 villages in Puntland, Somalia

Key finding

Mothers valued the trusted, home-based support and reduced access barriers

Practitioner

Mohamed et al. · OpenAlex · 3 Sept 2026

Survival

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Problem

High malaria morbidity and mortality among young children in areas with year-round malaria transmission

Intervention: Introduction of the RTS,S/AS01 malaria vaccine (4-dose schedule) through routine immunisation services
Population: Children under 5 years in pilot areas of Kenya, Ghana, and Malawi with moderate to high malaria incidence

Key finding

Phase 3 trial (2009-2014) showed 39% reduction in uncomplicated malaria and 32% reduction in severe malaria with 4 doses over 4 years

Experimental

Milligan · OpenAlex · 16 Sept 2026

SurvivalDevelopment

Problem

Iodine deficiency in utero and infancy leading to increased child mortality and reduced academic achievement

Intervention: Salt iodization program (and the effects of its disruption)
Population: Rural Ethiopian children born before and after the May 1998 border closure that interrupted iodized salt access

Key finding

Children with fewer months of early-life exposure to iodized salt scored lower on standardized secondary-school exams

Experimental

Alemu et al. · OpenAlex · 3 Sept 2026

Survival

Problem

High maternal and under-five mortality and limited access to maternal and child health services in West Africa

Intervention: Health insurance coverage for mothers and children
Population: Mothers and children in West African countries

Key finding

In most study settings, health insurance increased access to child and maternal health services

Practitioner

Dadjo et al. · Crossref · 23 Aug 2023

Survival

Problem

Iron and zinc deficiencies among children aged 6-24 months in Northern Uganda, linked to poorly processed complementary foods with high anti-nutrient content.

Intervention: Malting (sprouting/processing) of iron-rich bean flour combined with broken rice at different ratios to create complementary food formulations.
Population: Complementary food formulations intended for children aged 6-24 months; sensory evaluation conducted with 124 mothers of children in this age range.

Key finding

Malting increased iron, zinc, calcium, magnesium, potassium and fiber content compared to unmalted samples.

Practitioner

Atibo et al. · OpenAlex · 3 Sept 2026

SurvivalDevelopment

Problem

Growth and nutritional status concerns in children and adolescents with HIV-1 starting antiretroviral therapy

Intervention: Dolutegravir-based antiretroviral therapy
Population: Children and adolescents with HIV-1 initiating or switching to dolutegravir-based ART (238 total participants across two trials)

Key finding

Adjusted mean BMI-for-age z-score increased significantly by 0.3 in one trial (p<0.05) and non-significantly by 0.3 in the other (p=0.074).

Pre/post

McKenna et al. · OpenAlex · 12 Sept 2026

SurvivalDevelopment

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Problem

Micronutrient deficiencies and low essential fatty acid intake among pregnant/lactating women and young children in Sub-Saharan Africa, affecting growth and development

Intervention: Small-quantity lipid-based nutrient supplements (SQ-LNS) given to women and/or children to provide extra micronutrients, essential fatty acids and protein
Population: Pregnant/lactating women and children aged 6 months and older in six Sub-Saharan African countries

Key finding

Improved child growth in Ghana, Burkina Faso, Kenya, Zimbabwe and South Africa but not in two Malawi trials

Experimental

Adu‐Afarwuah · Crossref · 1 Dec 2020

Survival

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Problem

Relapse into malnutrition among children after treatment in a fragile, conflict-affected setting in Mali

Intervention: Community-based provision of Small-Quantity Lipid-Based Nutrient Supplements (SQ-LNS) combined with structured community growth monitoring, guided by a participatory Theory of Change
Population: Children treated for malnutrition and their mothers/caregivers in Mali

Key finding

The Theory of Change mapped operational, household, and environmental constraints driving post-treatment relapse.

Practitioner

Otekunrin et al. · OpenAlex · 14 Sept 2026

Survival

Problem

Persistent severe malnutrition in children with sickle cell anemia despite initial nutritional treatment

Intervention: Higher-intensity, weight-based ready-to-use therapeutic food (RUTF) combined with hydroxyurea medication
Population: Children aged 5-12 years with sickle cell anemia and severe malnutrition (BMI z-score below -3.0) after 12 weeks of initial RUTF treatment

Key finding

49% (53/108) of children had resolved severe malnutrition by Week 24, up from 39% at Week 12

Pre/post

Gambo et al. · OpenAlex · 17 Sept 2026

Survival

Problem

High rates of stunting among children aged 6-23 months in Zambia linked to poor infant and young child feeding practices

Intervention: Recommended infant and young child feeding (IYCF) practices, including breastfeeding, minimum dietary diversity, and minimum meal frequency
Population: Children aged 6-23 months in Zambia

Key finding

Breastfeeding reduced odds of stunting by 38%

Practitioner

Crossref · 1 Feb 2022

SurvivalDevelopment

Problem

High under-five mortality and chronic malnutrition (stunting) in Burkina Faso

Intervention: Multisectoral Nutrition Strategic Plan interventions including complementary feeding, breastfeeding promotion, malaria prevention in pregnancy, zinc supplementation, and WASH measures
Population: Children under five in Burkina Faso

Key finding

Under-five mortality projected to decline from 85.4 to 80.6 (MNSP) or 73.6 (MNSP+) per 1000 live births

Practitioner

Kere et al. · OpenAlex · 19 Sept 2026

Evidence on children's well-being, problem first.

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Evidence on children's well-being, problem first.